Laser Assisted Hatching


“Laser-assisted hatching - a better method for increasing pregnancy rate.”

Laser-assisted hatching is an additional procedure performed in a couple who are undergoing IVF treatment but are consistently embracing failure. The scenario arises especially in woman over 37 years of age, who generates harder zone pellucid and prevents the eggs from hatching. Failure to do so restricts women from conceiving and leaves them in despair.

Laser-assisted hatching increases the likelihood of improving the chances of pregnancy. The embryologist performs several tests to examine the embryo. Once embryos are created, it gets surrounded by the hard outer layer of cells called zona pellucid. Thereafter, to develop pregnancy, the embryo must break free from the shell to get implanted in the uterus. The overall concept of laser-assisted hatching is to assist embryo hatch from the shell by creating a small crack instead of creating a bigger gap.

Clinical studies state that the laser-assisted hatching inclines the chance of implantation of transferred embryos, which upon understanding the requirement of Nepalese couple Vatsalya has introduced an advanced form of laser-assisted hatching.

Types of assisted hatching methods

Most of the clients presume that the assisted hatching process involves a tear in zona pellucid or a small break. There are several methods of assisted hatching mainly:

  • Mechanical hatching

    With a pipette, the embryologist keeps the embryo steady. A micro-needle is used to puncture the zona pellucid to go underneath the shell. The area in between the puncture is rubbed till a small tear occurs. In this method it’s difficult to control the size of the opening, therefore the mechanical hatching is not much recommended by the embryologist. 
  • Mechanical expansion of the shell

    In this, you don’t break the zona pellucid, instead hydrostatic pressure is introduced. In this process, there is a natural expansion of the outer shell. The hydrostatic pressure can likely damage the embryo. 
  • Chemical hatching

    Tyrode’s acid is used to the zona pellucid until the shell is breached. Quickly, the embryo is cleaned to avoid unnecessary acid exposure.
  • Laser-assisted hatching

    The laser-assisted hatching procedure involves sending a strong light beam under a microscope to create a gap in a shell through the embryo. The laser hatching process is done for three days after fertilization (Intracytoplasmic Sperm Injection (ICSI) cycle or IVF. The whole laser hatching process takes up a few minutes and has no side effect on the embryo. On completion of the laser hatching in IVF, the embryo is then transferred back to the female uterus, which shall then continue to grow.

Of all the assisted hatching method, laser-assisted hatching procedure is the safest and effective techniques. However, rare embryology labs in Nepal are equipped to perform the advanced laser hatching embryo, including Vatsalya, the only fertility clinic in Nepal, equipped with the latest laser-assisted hatching process and experienced embryologist who aim to make a vast difference in their patients' life.

Who is recommended for Laser-Assisted Hatching Process?

Any patients deprived of the IVF success can take advantage of the laser-assisted hatching procedure. Females choosing to perform frozen embryo transfer with laser-assisted hatching are the best-suited candidates for laser hatching. However, the healthcare provider shall suggest the hatching process to the following:

  • Females above 37 years of age.
  • Patients whose zone pellucid is unusually thick.
  • Whose embryos are not well developed.
  • Individuals with elevated FSH levels on the follicular period.
  • Women who have faced constant failure in IVF cycles.

Several factors prevent an embryo from hatching successfully. The zona pellucid is often harder in the women above 37-years or older even after 2 or 3 days of embryo transfer. The process becomes difficult and harmful when trying to hatch fresh embryos via laser-assisted hatching. For such kinds of patient, extra tests and the advance procedure is opted by Vatsalya, as we believe that all the infertile pair can take advantage of our advanced laser-assisted hatching process.

How can an infertile pair gain from laser-assisted hatching?

Scientifically, the laser-assisted hatching process is performed under high-tech and by high-end expertise to get the desired result. Due to the rising percentage of infertility cases, laser-assisted hatching is a breakthrough process improvising the infertility treatments. Few of the benefits of the process include:

  • Improves the chances of implantation

    The whole procedure of laser-assisted hatching inclines the hope of implantation.
  • Declines multiple pregnancies

    It reduces the number of embryos transferred back to women, for one or two embryos can be swiftly moved after the laser hatching procedure. Blastocyst culture - It refers to a period of 3-4 days in which the embryos are monitored.
  • Minimum side effects

    The process is gentle, safe, with no negative effects on the embryo.

Laser-assisted hatching risks

There is an increased risk for identical twins in embryos who have undergone laser-assisted hatching. Very rare are the possibilities for an embryo to get damaged from the laser hatching. The only medical complications are the possibilities of identical twins’ in a single pregnancy. Further, the consumption of antibiotics and steroids can cause a few common medicational side effects which are tolerable. 

We aspire to build beautiful families! Vatsalya is committed to ensuring advanced treatments of laser-assisted hatching, therefore to know more about the service, contact us today!

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